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Cyclopentenone prostaglandin : ウィキペディア英語版 | Cyclopentenone prostaglandin
Cyclopentenone prostaglandin (cyPG) is a type of prostaglandin, a molecule which regulates inflammation and other processes. It is a potential new target for anti-inflammatory actions. It is thought to prevent the inflammatory pathway by inhibiting the activation of NF-κB, a transcription factor in cell reproduction. The cyclopentenone prostaglandin known as 15d-PGJ2 has been shown to inhibit a gene in T cells which is active in inflammation, such as in various autoimmune diseases.〔Fionda, C., et al. (2007). (Inhibition of ''Trail'' gene expression by cyclopentenonic prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T lymphocytes ). ''Molecular Pharmacology'' 72:5 1246-57.〕〔Cernuda-Morollón, E., et al. (2001). (15-Deoxy-Δ12,14-prostaglandin J2 Inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit ). ''Journal of Biological Chemistry'' 276 35530-36.〕 15d-PGJ2 is also demonstrated to suppress hair growth and is implicated in male pattern baldness. ==References==
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